Mettine H.A. Bos, Ph.D.

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Postdoctoral Fellow
The Children's Hospital of Philadelphia

Education and Training

Amsterdam and Utrecht University, Utrecht, the Netherlands. (PhD, 2006). Thesis: "Regulatory mechanisms in the inactivation of blood coagulation factors V and VIII"

Free University, Amsterdam, the Netherlands. (MSc, 2000)

Research Interests

I am interested in the structural determinants on blood coagulation factor V that are important for its procofactor to cofactor transition. By developing novel factor V variants and by functionally characterizing them, I aim at further uncovering a specific factor V region that contribute to this transition. In addition, I am also investigating evolutionary aspects of the B-domain of factor V, as certain vertebrates appear to have specific inhibitory B-domain sequences while others do not. Since July 2008, when I was awarded the Judith Graham Pool Postdoctoral Research Fellowship , I have extended my research focus from factor V to the molecular mechanism of factor VIII activation. Both lines of research may provide a framework for developing cofactor derivatives with novel therapeutic properties.

Publications

Bos M.H.A., Boltz M., St. Pierre L., Masci P.P., de Jersey J., Lavin M.F., Camire R.M. Venom factor V from the common brown snake escapes hemostatic regulation through procoagulant adaptations. Blood, In Press.

Bos M.H.A., Meijerman D.W.E., van der Zwaan C., Mertens K. Does activated protein C-resistant factor V contribute to hemophilic plasma? J. Thromb. Haemost. 3: 522-530, 2005.

Post S.M., Zoetewij J.P., Bos M.H.A., de Wit E.C.M., Princen H.M.G. The ACAT inhibitor avasimibe stimulates bile acid synthesis and cholesterol 7-hydroxylase in cultured rat hepatocytes and in vivo in rat. Hepatology 30: 491-500, 1999.

Contact Information

Email: bos@email.chop.edu

Phone: 215-590-3873 (Lab)