Lacramioara Ivanciu, Ph.D.

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Postdoctoral Fellow
The Children's Hospital of Philadelphia

Education and Training

University of Bucharest, Romania
Oklahoma Medical Research Foundation, OK
Ph.D., November 2004

Research Projects

Use zymogen-like FXa variants which can be thermodynamically rescued by FVa to examine whether they provide effective hemostasis using in vivo models of hemophilia.

Publications

Fu J, Gerhardt H, McDaniel JM, Xia B, Liu X, Ivanciu Lacramioara, Ny A, Hermans K, Silasi-Mansat R, McGee S, Nye E, Ju T, Ramirez MI, Carmeliet P, Cummings RD, Lupu F, Xia L. Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest. 2008 Nov; 118(11):3725-37.

Towner RA, Smith N, Doblas S, Tesiram Y, Garteiser P, Saunders D, Cranford R, Silasi-Mansat R, Herlea O, Lacramioara Ivanciu, Wu D, Lupu F. In vivo detection of c-Met expression in a rat C6 glioma model. J Cell Mol Med. 2008 Jan-Feb; 12(1):174-86.

H Tang, Lacramioara Ivanciu, G Peer, C Lupu, F B. Taylor, Jr., F Lupu. Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor. Am. J. Pathol., 2007, Sep; 171(3):1066-77.

Lacramioara Ivanciu, Robert D. Gerard, Haiwang Tang, Cristina Lupu, Florea Lupu. Adenovirus Mediated Expression of Tissue Factor Pathway Inhibitor-2 Inhibits Endothelial Cell Migration and Angiogenesis. Arterioscler Thromb Vasc Biol. 2007 Feb; 27:310-316.

Zhu H, Tang Y, Ivanciu Lacramioara, Centola M, Lupu C, Taylor FB Jr, Lupu F. Temporal dynamics of gene expression in the lung in a baboon model of E. coli sepsis. BMC Genomics. 2007 Feb 26; 8:58.

Lupu, C., Westmuckett, A., Peer, G., Ivanciu Lacramioara, Zhu, H., Taylor, JB., Lupu, F. Tissue factor-dependent coagulation is preferentially upregulated within arterial branching areas in a baboon model of E. coli sepsis. Am J Pathol. 2005 Oct; 167(4): 1161-72.

Xia, L., Ju, T., Westmuckett, A., Gu, A., Ivanciu Lacramioara, McDaniel, JM, Lupu, F., Cummings, RD., McEver, RP. Defective Angiogenesis and fatal embryonic hemorrhage in mice lacking core-1-derived O-glycan, J. Cell Biology. 2004 Feb 2; 164(3): 451-9.

Contact Information

Email: ivanciu@email.chop.edu

Phone: 215-590-3873 (Lab)