Faculty Profile - Shekhar Kumar

Kumar

Shekhar Kumar, PhD

Education and Training

PhD 2009, Institute of Microbial Technology, Chandigarh, India
Thesis: "Studies on concerted structural transitions and protein‐protein interactions in plasminogen activation by bacterial plasminogen activators"

M.Sc 2003, All India Institute of Medical Sciences, New Delhi, India

Research Interests

My interest lies in exploring the role of macromolecular interactions as a modulator of enzyme's substrate specificity and inordinately high processivity. More specifically, I am exploring the highly regulated proteolytic processing of prothrombin to its active form thrombin (factor IIa) by prothrombinase enzyme complex. My efforts would be to take a multidisciplinary approach involving biochemical, structural and biological studies in order to unravel the details of prothrombinase assembly and its highly ordered action on macromolecular substrate, prothrombin. A deep understanding of this system may render development of new therapeutics through catalytic creativity or cofactor alteration.

Contact

Email: kumars@email.chop.edu
Phone: 215-485-0324