Publications
- Zheng X, Geiger M, Ecke S, Bielek E, Donner P, Eberspacher U, Schleuning WD, Binder BR
Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa
Date: 1994
Am J Physiol . Aug;267(2 Pt 1):C466-72
- Geiger M, Zechmeister-Machhart M, Uhrin P, Hufnagl P, Ecke S, Priglinger U, Xu J, Zheng X, Binder BR
Protein C inhibitor (PCI).
Date: 1996
Immunopharmacology, May;32(1-3):53-6. Review
- Hendry WJ 3rd, Zheng X, Leavitt WW, Branham WS, Sheehan DM
Endometrial hyperplasia and apoptosis following neonatal diethylstilbestrol exposure and subsequent estrogen stimulation in both host and transplanted hamster uteri.
Date: 1997
Cancer Res . May 15;57(10):1903-8
- Zheng X, and W. Hendry III
Neonatal diethylstilbestrol treatment alters the estrogen-regulated expression of both cell proliferation and apoptosis-related proto-oncogenes (c-jun, c-fos, c-myc, bax, bcl-2, and bcl-x) in the hamster uterus.
Date: 1997
Cell Growth Differ. Apr;8(4): 425-34
- Lu D, Yuan X, Zheng X, Sadler JE
Bovine proenteropeptidase is activated by trypsin, and the specificity of enteropeptidase depends on the heavy chain.
Date: 1997
J Biol Chem. 272(50): 31293-300
- Kokame K, Zheng X, Sadler JE
Activation of thrombin-activable fibrinolysis inhibitor requires epidermal growth factor-like domain 3 of thrombomodulin and is inhibited competitively by protein C.
Date: 1998
J Biol Chem. 273(20): 12135-9
- Xue J, Wu Q, Westfield LA, Tuley EA, Lu D, Zhang Q, Shim K, Zheng X, Sadler JE
Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice.
Date: 1998
Proc Natl Acad Sci U S A. 95(13): 7603-7
- Yuan X, Zheng X, Lu D, Rubin DC, Pung CY, Sadler JE
Structure of murine enterokinase (enteropeptidase) and expression in small intestine during development.
Date: 1998
Am J Physiol. 274(2 pt 1): G342-9
- Zheng X, Lu D, Sadler JE
Apical sorting of bovine enteropeptidase does not involve detergent-resistant association with sphingolipid-cholesterol rafts.
Date: 1999
J Biol Chem. 274(3): 1596-605
- Zheng X, Chung D, Takayama TK, Majerus EM, Sadler JE, Fujikawa K
Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura.
Date: 2001
J Biol Chem. 276(44): 41059-63
- Zheng X, Sadler JE
Mucin-like domain of enteropeptidase directs apical targeting in Madin-Darby canine kidney cells.
Date: 2002
J. Biol. Chem. 277(9): 2858-63
- Zheng X, Majerus EM, Sadler JE
ADAMTS13 and TTP.
Date: 2002
Curr. Opin.Hematology 9(5): 389-94
- Majerus E, Zheng X, Tuley EA, Sadler JE
Cleavage of the ADAMTS13 propeptide is not required for protease activity.
Date: 2003
J. Biol. Chem. 278: (47):46643-48.
- Zheng X, K. Nishio, E.M. Majerus, J.E. Sadler
Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13.
Date: 2003
J. Biol. Chem. 278 30136-30141, 2003. 278(32): 30136-30141
- Zheng X, Pallera AM, Goodnough LT, Sadler JE, Blinder MA
Remission of chronic thrombotic thrombocytopenic purpura after treatment with cyclophosphamide and rituximab.
Date: 2003
Ann Intern Med 138(2): 105-108
- Nishio K, Zheng X., and J. E. Sadler
Binding of platelet glycoprotein Iba to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.
Date: 2004
Proc. Natl. Acad. Sci. 101(29): 10578-10583
- Zheng X., Kaufman R.M., Goodnough L.T. and J.E. Sadler
Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and non-idiopathic thrombotic thrombocytopenic purpura.
Date: 2004
Blood 103(11): 4043-49 .
- Ai J, Smith P, Wang S, Zhang P, X Zheng
The proximal carboxyl terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of Von Willebrand factor.
Date: 2005
J. Biol. Chem. 280(33): 29428-29434.
- Shelat S, Ai J, and X Zheng
Molecular biology of ADAMTS13 and Diagnostic Utilities of ADAMTS13 assay
Date: 2005
Semin. Thromb. Hemostat. 31 (6):659-72.
- Shang D., J. Ai, Li N, and X Zheng
Apical sorting of ADAMTS13 in endothelial and MDCK cells depend on CUB domains and its interaction with detergent-insoluble glycosphingolipid- and cholesterol-enriched rafts.
Date: 2006
Blood 108 (7): 2207-15.
- Shelat S., Smith P., Ai J, and X Zheng
Inhibitory autoantibodies against ADAMTS-13 in patients with thrombotic thrombocytopenic purpura bind ADAMTS13 protease and may accelerate its clearance in vivo.
Date: 2006
J. Thromb. Haemonst. 4: 1707-17.
- Niiya M, Uemura M, Zheng XW, Dockal M, Scheiflinger F, Wells R, Pollak E and X. Zheng
Increased ADAMTS-13 proteolytic activity in rat hepatic stellate cells upon activation in vitro and in vivo.
Date: 2006
J. Thromb. Hemost. 4:1063-70.
- Cataland S.R, Jin M, X.L. Zheng, George J.M, and H.F. Wu.
An evaluation of cyclosporine alone for the treatment of early recurrences of thrombotic thrombocytopenic purpura.
Date: 2006
J. Thromb. Hemost. 4(5): 1162-1164.
- Bennett C.L., B. Kim, A. Zakarija, N.Bandarenko, D.K. Pandey, C.G. Buffie, J.M. McKoy, A.D. Tevar, J.F. Cursio, P.R. Yarnold, H.C. Kwaan, D.D. Masi, R. Sarode, T.J. Raife, J.E. Kiss, D.W. Raisch, C.Davidson, J.E. Sadler, T. L. Ortel, X.L. Zheng, S.Kato, M. Matsumoto, M. Uemura, and Y. Fujimura.
Two Mechanistic Pathways for Thienopyridine-Associated Thrombotic Thrombocytopenic Purpura.
Date: 2007
J. Am. Coll. Cardiol. 50(12):1138-43.
- Zhang P., Pan W., Rux A.H., Sachais B.S., and X.L. Zheng.
The Cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow.
Date: 2007
Blood 110(6): 1887-94.
- Zheng X.L. and J.E. Sadler.
Pathogenesis of Thrombotic Microangiopathies.
Date: 2008 (annual review)
Ann. Rev. Pathol. Dis. Mech. 3: 249-77.