Matthew Bunce, Ph.D.

« Back to Members

Postdoctoral Fellow
The Children's Hospital of Philadelphia

Education and Training

Virginia Polytechnic Institute & State University
Dept. of Biochemistry
B.S. (1999)

Univeristy of Wisconson – Madison
Dept. of Biomolecular Chemistry
Ph.D. (2007)

Research Projects

Characterization of "zymogen-like" FXa variants as bypass agents to rescue thrombin generation in hemophilic plasma.

Role of FVa in exosite expression and prothrombin activation by prothrombinase.

Publications

Bunce MW, Boronenkov IV, Anderson RA. Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate. J Biol Chem. 2008 Mar 28;283(13):8678-86. Epub 2008 Jan 24. PubMed PMID: 18218622.

Bunce MW, Gonzales ML, Anderson RA. Stress-ING out: phosphoinositides mediate the cellular stress response. Sci STKE. 2006 Nov 7;2006(360):pe46. PubMed PMID: 17090802.

Bunce MW, Bergendahl K, Anderson RA. Nuclear PI(4,5)P(2): a new place for an old signal. Biochim Biophys Acta. 2006 May-Jun;1761(5-6):560-9. Epub 2006 Mar 29. Review. PubMed PMID: 16750654

Doughman RL, Firestone AJ, Wojtasiak ML, Bunce MW, Anderson RA. Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling. J Biol Chem. 2003 Jun 20;278(25):23036-45. Epub 2003 Apr 6. PubMed PMID: 12682053.

Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA. Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature. 2002 Nov 7;420(6911):89-93. PubMed PMID: 12422220.

Contact Information

Email: buncem@email.chop.edu

Phone: 215-590-3873 (Lab)