Publications
| Author(s) and Date | Title, Publication, and Volume | |
| Harlan N. Bradford, Joseph A. Micucci and Sriram Krishnaswamy (2010) | Regulated Cleavage of Prothrombin by Prothrombinase: Repositioning a Cleavage Site Reveals the Unique Kinetic Behavior of the Action of the Prothrombinase on Its Compound Substrate. Journal of Biological Chemistry 2010;285:328-338. |
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| Parvathi Kamath, James A. Huntington and Sriram Krishnaswamy (2010) | Ligand binding shuttles thrombin along a continuum of zymogen-like and proteinase-Like states. Journal of Biological Chemistry 2010;M110.154914. |
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| Buddai, Sai K; Layzer, Juliana M; Lu, Genmin; Rusconi, Christopher P; Sullenger, Bruce A; Monroe Dougald M; Krishnaswamy, Sriram (2010) | An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase. Journal of Biological Chemistry 2010;285:5212-23. |
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| Krishnaswamy Sriram (2009) | Supercharged blood coagulation. Blood 2009;113(9):1873-4. |
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| Kamath Parvathi; Krishnaswamy Sriram (2008) | Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase. The Journal of biological chemistry 2008;283(44):30164-73. |
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| Cao Wenjing; Krishnaswamy Sriram; Camire Rodney M; Lenting Peter J; Zheng X Long (2008) | Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13. Proceedings of the National Academy of Sciences of the United States of America 2008;105(21):7416-21. |
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| Hacisalihoglu A., Panizzi P., Bock P.E., Camire R.M., Krishnaswamy S. (2007) | Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase. J Biol Chem. 2007 Nov 9;282(45):32974-82. |
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| Schmidt, A. E., Stewart, J. E.. Mathur, A. Krishnaswamy, S. and Bajaj, S. P (2005) | Na+ Site in Blood Coagulation Factor IXa: Effect on Catalysis and Factor VIIIa Binding Journal of Molecular Biology. 1 July 2005, Pages 78-91 |
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| Bianchini, E. P., Orcutt, S. J., Panizzi P., Bock, P.E. and Krishnaswamy S. (2005) | Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase PNAS, vol. 102, no. 29 | 10099-10104 |
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| Lu, G., Chhum S., and Krishnaswamy S. (2005) | The Affinity of Protein C for the Thrombin-Thrombomodulin Complex is Determined in a Primary Way by Active Site-Dependent Interactions. J. Biol.Chem., 280 No.15. 15471-15478 |
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| Krishnaswamy S. (2005) | Exosite-driven substrate specificity and function in coagulation Journal of Thrombosis and Haemostasis 3:54-67 |
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Orcutt S. J., Krishnaswamy S. (2004) |
Binding of substrate in two conformations to human prothrombinase drives consecutive cleavage at two sites in prothrombin. J. Biol. Chem., Vol. 279, 54927-54936 |
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| Boskovic, D.S.,Troxler, T. and Krishnaswamy, S. (2004) | Active Site-independent Recognition of Substrates and Product by Bovine Prothrombinase A FLUORESCENCE RESONANCE ENERGY TRANSFER STUDY* J. Biol. Chem., 279, 20786-20793 |
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| Lu, G. J. Broze, and S. Krishnaswamy (2004) | Formation of factors IXa and Xa by the extrinsic pathway: Differential regulation by tissue factor pathway inhibitor and antithrombin III J. Biol. Chem., 279, 17241-17249 |
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| Orcutt, S., Pietropaolo, C. and Krishnaswamy, S. (2002) | Extended Interactions with the Macromolecular Substrate Enforce Affinity and Specificity in Prothrombinase Function J. Biol. Chem., 277, 46191-46196 JBC -- About the Cover (November 2002, 277, (48)) |
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| Buddai, S. K. , Toulokhonova, L., Bergum, P.W., Vlasuk, G.P., and Krishnaswamy, S (2002) | Nematode anticoagulant protein c2 reveals a site on factor Xa that is important for macromolecular substrate binding to human prothrombinase. J. Biol. Chem. 277, 26689-26698 |
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| Wilkens, M. and Krishnaswamy, S. (2002) | The contribution of factor Xa to exosite-dependent substrate recognition by prothrombinase J. Biol. Chem 277, 9366-9374 JBC -- About the Cover (March 2002, 277, (11) |
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| Boskovic, D.S. and Krishnaswamy, S. (2000) | Exosite binding tethers the macromolecular substrate to the prothrombinase complex and directs cleavage at two spatially distinct sites J. Biol. Chem., 275, 38561-38570 |
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| Baugh, R.J., Dickinson, C.D., Ruf, W. and Krishnaswamy, S. (2000) | Exosite interactions determine the affinity of factor X for the extrinsic Xase complex J. Biol. Chem., 275, 28826-28833 |
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| Betz, A. and Krishnaswamy, S. (1998) | Regions remote from the site of cleavage determine macromolecular substrate recognition by the prothrombinase complex. J. Biol. Chem., 273, 10709-10718 |
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| Baugh, R.J., Broze, G.J. and Krishnaswamy, S (1998) | Regulation of Extrinsic Pathway Factor Xa Formation by Tissue Factor Pathway Inhibitor J. Biol. Chem., 273, 4378-4386 |
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| Krishnaswamy, S. and Betz, A. (1997) | Exosites Determine Macromolecular Substrate Recognition by Prothrombinase Biochemistry, 36, 12080 -12086 |
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| Krishnaswamy, S. and Walker, R.K. (1997) | Contribution of the Prothrombin Fragment 2 Domain to the Function of Factor Va in the Prothrombinase Biochemistry 36, 3319-3330 |
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| Betz, A., Vlasuk, G.P., Bergum, P.W. and Krishnaswamy, S. (1997) | Selective Inhibition of the Prothrombinase Complex: Factor Va alters macromolecular recognition of a tick anticoagulant peptide mutant by factor Xa Biochemistry 36, 181-191 |
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| Cutsforth, G.A., Koppaka, V., Krishnaswamy, S., Wu, J.R., Mann, K.G. and Lentz, B.R. (1996) | Insights into the Complex Association of Bovine Factor Va with Acidic-Lipid Containing Synthetic Membranes Biophysical Journal, 70, 2938-2949 |
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| Baugh, R.J. and Krishnaswamy, S (1996) | Role of the Activation Peptide in the Activation of Human Factor X by the Extrinsic Xase Complex J. Biol. Chem. 271, 16126-16134 |
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| Walker, R.K. and Krishnaswamy, S. (1994) | The activation of Prothrombin by the Prothrombinase Complex: Contribution of the substrate-membrane interaction to catalysis J. Biol. Chem. 269, 27441-27450 |
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| Barrow, R.T., Parker, E.T., Krishnaswamy, S., and Lollar, P. (1994) | Inhibition by heparin of the human blood coagulation intrinsic pathway factor X activator. J. Biol. Chem. 269, 26796-26800 |
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| Krishnaswamy, S., Vlasuk, G.P., and Bergum, P.W. (1994) | Assembly of the Prothrombinase Complex Enhances the Inhibition of Bovine Factor Xa by Tick Anticoagulant Peptide Biochemistry 33, 7897-7907 |
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| Walker, R.K. and Krishnaswamy, S. (1993) | The Influence of Factor Va on the Active Site of Factor Xa. J. Biol. Chem.. 268, 13920-13929 |
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| Lawson, J. H., Krishnaswamy, S., Butenas, S., and Mann, K. G. (1993) | Extrinsic Pathway Proteolytic Activity Methods Enzymol. 222, 177-195 |
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| Kalafatis, M., Krishnaswamy, S., Rand, M. D., and Mann, K. G. (1993) | Factor V. Methods Enzymol. 222, 224-236 |
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| Krishnaswamy, S., Nesheim, M. E., Pryzdial, E. L., and Mann, K. G. (1993) | Assembly of the prothrombinase complex. Methods Enzymol.222, 260-280 |
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| Krishnaswamy, S., Field, K.A., Edgington, T.S., Morrissey, J.H., and Mann, K.G. (1992) | Role of the membrane surface in the activation of human factor X J. Biol. Chem. 267, 26110-26120 |
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| Krishnaswamy, S. (1992) | The Interaction of factor VIIa with human tissue factor J. Biol. Chem. 267, 23696-23706 |
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| Mann, K.G., Williams, E.B., Krishnaswamy, S., Church, W.R., Giles, A., and Tracy, R.P. (1990) | Active-site specific immunoassays Blood 76, 755-766 |
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| Mosesson, M.W., Church, W.R., DiOrio, J.P., Krishnaswamy, S., Mann, K.G., Hainfeld, J.F., and Wall, J.S. (1990) | Structural Model of Factors V and Va Based on Scanning Transmission Electron Microscope Images and Mass Analysis Biol. Chem. 265, 8863-8868 |
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| Krishnaswamy, S. (1990) | Prothrombinase complex assembly. Contributions of protein-protein and protein-membrane interactions toward complex formation J. Biol. Chem. 265, 3708-3718 |
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| Mann, K. G., Nesheim, M. E., Church, W. R., Haley, P., and Krishnaswamy, S. (1990) | Surface-dependent reactions of the vitamin K-dependent enzyme complexes Blood 76, 1-16 |
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| Williams, E.B., Krishnaswamy, S., and Mann, K.G. (1989) | Zymogen/Enzyme Discrimination using Peptide Chloromethyl Ketones J. Biol. Chem. 264, 7536-7545 |
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| Gendreau, M.A., Krishnaswamy, S., and Mann, K.G. (1989) | The interaction of bone Gla protein (osteocalcin) with phospholipid vesicles. Biol. Chem. 24, 6972-6978 |
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| Krishnaswamy, S., Russell, G.D., and Mann, K.G. (1989) | The Reassociation of Factor Va from its Isolated Subunits. J. Biol. Chem.264, 3160-3168 |
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| Krishnaswamy, S., Jones, K.C., and Mann, K.G. (1988) | Prothrombinase Complex Assembly: Kinetic Mechanism of Enzyme Assembly on Phospholipid Vesicles. J. Biol. Chem. 263, 3823-3834 |
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| Krishnaswamy, S. and Mann, K.G. (1988) | The Binding of Factor Va to Phospholipid Vesicles. J. Biol. Chem. 263, 5714-5723 |
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| Lecompte, M.F., Krishnaswamy, S., Mann, K.G., Nesheim, M.E., and Gitler, C. (1987) | Membrane penetration of bovine factor V and Va detected by labeling with 5-iodonaphthalene-1-azide. J. Biol. Chem. 262, 1935-1937 |
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| Krishnaswamy, S., Church, W.R., Nesheim, M.E., and Mann, K.G. (1987) | Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism. J. Biol. Chem. 262, 3291-3299 |
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| Krishnaswamy, S., Williams, E.B., and Mann, K.G. (1986) | The binding of activated protein C to factors V and Va. J. Biol. Chem. 261, 9684-9693 |
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| Krishnaswamy, S., Mann, K.G., and Nesheim, M.E. (1986) | The prothrombinase- catalyzed activation of prothrombin proceeds through the intermediate meizothrombin in an ordered, sequential reaction. J. Biol. Chem. 261, 8977-8984 |
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