Author(s) and Date Title, Publication, and Volume
  Harlan N. Bradford, Joseph A. Micucci and Sriram Krishnaswamy (2010) Regulated Cleavage of Prothrombin by Prothrombinase: Repositioning a Cleavage Site Reveals the Unique Kinetic Behavior of the Action of the Prothrombinase on Its Compound Substrate.
Journal of Biological Chemistry 2010;285:328-338.
  Parvathi Kamath, James A. Huntington and Sriram Krishnaswamy (2010) Ligand binding shuttles thrombin along a continuum of zymogen-like and proteinase-Like states.
Journal of Biological Chemistry 2010;M110.154914.
  Buddai, Sai K; Layzer, Juliana M; Lu, Genmin; Rusconi, Christopher P; Sullenger, Bruce A; Monroe Dougald M; Krishnaswamy, Sriram (2010) An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase.
Journal of Biological Chemistry 2010;285:5212-23.
  Krishnaswamy Sriram (2009) Supercharged blood coagulation.
Blood 2009;113(9):1873-4.
  Kamath Parvathi; Krishnaswamy Sriram (2008) Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase.
The Journal of biological chemistry 2008;283(44):30164-73.
  Cao Wenjing; Krishnaswamy Sriram; Camire Rodney M; Lenting Peter J; Zheng X Long (2008) Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(21):7416-21.
  Hacisalihoglu A., Panizzi P., Bock P.E., Camire R.M., Krishnaswamy S. (2007) Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase.
J Biol Chem. 2007 Nov 9;282(45):32974-82.
  Schmidt, A. E.,  Stewart,  J. E.. Mathur, A.  Krishnaswamy, S. and Bajaj, S. P (2005) Na+ Site in Blood Coagulation Factor IXa: Effect on Catalysis and Factor VIIIa Binding
Journal of Molecular Biology.
1 July 2005, Pages 78-91
  Bianchini, E. P., Orcutt, S. J., Panizzi P., Bock, P.E. and Krishnaswamy S. (2005) Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase
PNAS,  vol. 102, no. 29 | 10099-10104
  Lu, G., Chhum S., and Krishnaswamy S. (2005) The Affinity of Protein C for the Thrombin-Thrombomodulin Complex is Determined in a Primary Way by Active Site-Dependent Interactions.
J. Biol.Chem., 280 No.15. 15471-15478
  Krishnaswamy S. (2005) Exosite-driven substrate specificity and function in coagulation
Journal of Thrombosis and Haemostasis 3:54-67
Orcutt S. J., Krishnaswamy S. (2004)
Binding of substrate in two conformations to human prothrombinase drives consecutive cleavage at two sites in prothrombin.
J. Biol. Chem., Vol. 279, 54927-54936
  Boskovic, D.S.,Troxler,   T. and  Krishnaswamy, S. (2004) Active Site-independent Recognition of Substrates and Product by Bovine Prothrombinase
J. Biol. Chem., 279, 20786-20793
  Lu, G. J. Broze, and  S. Krishnaswamy (2004) Formation of factors IXa and Xa by the extrinsic pathway: Differential regulation by tissue factor pathway inhibitor and antithrombin III
J. Biol. Chem., 279, 17241-17249
  Orcutt, S., Pietropaolo, C. and Krishnaswamy, S. (2002) Extended Interactions with the Macromolecular Substrate Enforce Affinity and Specificity in Prothrombinase Function
J. Biol. Chem., 277, 46191-46196
JBC -- About the Cover (November 2002, 277, (48))
  Buddai, S. K. , Toulokhonova, L.,  Bergum, P.W., Vlasuk, G.P., and Krishnaswamy, S (2002) Nematode anticoagulant protein c2 reveals a site on factor Xa that is important for macromolecular substrate binding to human prothrombinase.
J. Biol. Chem. 277, 26689-26698
  Wilkens, M. and Krishnaswamy, S. (2002) The contribution of factor Xa to exosite-dependent substrate recognition by prothrombinase
J. Biol.  Chem  277, 9366-9374
JBC -- About the Cover (March 2002, 277, (11)
  Boskovic, D.S. and Krishnaswamy, S. (2000) Exosite binding tethers the macromolecular substrate to the prothrombinase complex and directs cleavage at two spatially distinct sites
J. Biol. Chem., 275, 38561-38570
  Baugh, R.J., Dickinson, C.D., Ruf, W. and Krishnaswamy, S. (2000) Exosite interactions determine the affinity of factor X for the extrinsic Xase complex
J. Biol. Chem., 275, 28826-28833
  Betz, A. and Krishnaswamy, S. (1998) Regions remote from the site of cleavage determine macromolecular substrate recognition by the prothrombinase complex.
J. Biol. Chem., 273, 10709-10718
  Baugh, R.J., Broze, G.J. and Krishnaswamy, S (1998) Regulation of Extrinsic Pathway Factor Xa Formation by Tissue Factor Pathway Inhibitor
J. Biol. Chem., 273, 4378-4386
  Krishnaswamy, S. and Betz, A. (1997) Exosites Determine Macromolecular Substrate Recognition by Prothrombinase
Biochemistry, 36, 12080 -12086 
  Krishnaswamy, S. and Walker, R.K. (1997) Contribution of the Prothrombin Fragment 2 Domain to the Function of Factor Va in the Prothrombinase
Biochemistry 36, 3319-3330
  Betz, A., Vlasuk, G.P., Bergum, P.W. and Krishnaswamy, S. (1997) Selective Inhibition of the Prothrombinase Complex: Factor Va alters macromolecular recognition of a tick anticoagulant peptide mutant by factor Xa
Biochemistry 36, 181-191
  Cutsforth, G.A., Koppaka, V., Krishnaswamy, S., Wu, J.R., Mann, K.G. and Lentz, B.R. (1996) Insights into the Complex Association of Bovine Factor Va with Acidic-Lipid Containing Synthetic Membranes
Biophysical Journal, 70, 2938-2949
  Baugh, R.J. and Krishnaswamy, S (1996) Role of the Activation Peptide in the Activation of Human Factor X by the Extrinsic Xase Complex
J. Biol. Chem. 271, 16126-16134
  Walker, R.K. and Krishnaswamy, S. (1994) The activation of Prothrombin by the Prothrombinase Complex: Contribution of the substrate-membrane interaction to catalysis
J. Biol. Chem. 269, 27441-27450
  Barrow, R.T., Parker, E.T., Krishnaswamy, S., and Lollar, P. (1994) Inhibition by heparin of the human blood coagulation intrinsic pathway factor X activator.
J. Biol. Chem. 269, 26796-26800 
  Krishnaswamy, S., Vlasuk, G.P., and Bergum, P.W. (1994) Assembly of the Prothrombinase Complex Enhances the Inhibition of Bovine Factor Xa by Tick Anticoagulant Peptide
Biochemistry 33, 7897-7907
  Walker, R.K. and Krishnaswamy, S. (1993) The Influence of Factor Va on the Active Site of Factor Xa.
J. Biol. Chem.. 268, 13920-13929
  Lawson, J. H., Krishnaswamy, S., Butenas, S., and Mann, K. G. (1993) Extrinsic Pathway Proteolytic Activity
Methods Enzymol. 222, 177-195
  Kalafatis, M., Krishnaswamy, S., Rand, M. D., and Mann, K. G. (1993) Factor V.
Methods Enzymol. 222, 224-236
  Krishnaswamy, S., Nesheim, M. E., Pryzdial, E. L., and Mann, K. G. (1993) Assembly of the prothrombinase complex.
Methods Enzymol.222, 260-280
  Krishnaswamy, S., Field, K.A., Edgington, T.S., Morrissey, J.H., and Mann, K.G. (1992) Role of the membrane surface in the activation of human factor X
J. Biol. Chem. 267, 26110-26120
  Krishnaswamy, S. (1992) The Interaction of factor VIIa with human tissue factor
J. Biol. Chem. 267, 23696-23706
  Mann, K.G., Williams, E.B., Krishnaswamy, S., Church, W.R., Giles, A., and Tracy, R.P. (1990) Active-site specific immunoassays
Blood 76, 755-766
  Mosesson, M.W., Church, W.R., DiOrio, J.P., Krishnaswamy, S., Mann, K.G., Hainfeld, J.F., and Wall, J.S. (1990) Structural Model of Factors V and Va Based on Scanning Transmission Electron Microscope Images and Mass Analysis
Biol. Chem. 265, 8863-8868
  Krishnaswamy, S. (1990) Prothrombinase complex assembly. Contributions of protein-protein and protein-membrane interactions toward complex formation
J. Biol. Chem. 265, 3708-3718
  Mann, K. G., Nesheim, M. E., Church, W. R., Haley, P., and Krishnaswamy, S. (1990) Surface-dependent reactions of the vitamin K-dependent enzyme complexes
Blood 76, 1-16
  Williams, E.B., Krishnaswamy, S., and Mann, K.G. (1989) Zymogen/Enzyme Discrimination using Peptide Chloromethyl Ketones
J. Biol. Chem. 264, 7536-7545
  Gendreau, M.A., Krishnaswamy, S., and Mann, K.G. (1989) The interaction of bone Gla protein (osteocalcin) with phospholipid vesicles.
Biol. Chem. 24, 6972-6978
  Krishnaswamy, S., Russell, G.D., and Mann, K.G. (1989) The Reassociation of Factor Va from its Isolated Subunits.
J. Biol. Chem.264, 3160-3168
  Krishnaswamy, S., Jones, K.C., and Mann, K.G. (1988) Prothrombinase Complex Assembly: Kinetic Mechanism of Enzyme Assembly on Phospholipid Vesicles.
J. Biol. Chem. 263, 3823-3834
  Krishnaswamy, S. and Mann, K.G. (1988) The Binding of Factor Va to Phospholipid Vesicles.
J. Biol. Chem. 263, 5714-5723
  Lecompte, M.F., Krishnaswamy, S., Mann, K.G., Nesheim, M.E., and Gitler, C. (1987) Membrane penetration of bovine factor V and Va detected by labeling with 5-iodonaphthalene-1-azide.
J. Biol. Chem. 262, 1935-1937
  Krishnaswamy, S., Church, W.R., Nesheim, M.E., and Mann, K.G. (1987) Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism.
J. Biol. Chem. 262, 3291-3299
  Krishnaswamy, S., Williams, E.B., and Mann, K.G. (1986) The binding of activated protein C to factors V and Va.
J. Biol. Chem. 261, 9684-9693
  Krishnaswamy, S., Mann, K.G., and Nesheim, M.E. (1986) The prothrombinase-
catalyzed activation of prothrombin proceeds through the intermediate meizothrombin in an ordered, sequential reaction.
J. Biol. Chem. 261, 8977-8984